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Abstract
ARALAR/AGC1 (aspartate‐glutamate mitochondrial carrier 1) is an important component of the NADH malate‐aspartate shuttle (MAS). AGC1‐deficiency is a rare disease causing global cerebral hypomyelination, developmental arrest, hypotonia, and epilepsy (OMIM ID #612949); the aralar‐KO mouse recapitulates the major findings in humans. This study was aimed at understanding the impact of ARALAR‐deficiency...
The mitochondrial aspartate‐glutamate carriers (AGC) aralar (SLC25A12) and citrin (SLC25A13) are components of the malate aspartate shuttle (MAS), a major intracellular pathway to transfer reducing equivalents from NADH to the mitochondrial matrix. Aralar is the main AGC isoform present in the adult brain, and it is expressed mainly in neurons. To search for the other AGC isoform, citrin, in brain...
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